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Abstract Introduction Cardiac surgeries are generally associated with high morbidity and mortality. To prevent any adverse outcomes, it is crucial to identify patients at risk of developing postoperative complications and initiate...
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Abstract Introduction Cardiac surgeries are generally associated with high morbidity and mortality. To prevent any adverse outcomes, it is crucial to identify patients at risk of developing postoperative complications and initiate relevant therapeutic interventions. Several biomarkers are used to determine postoperative myocardial injury but they either lack sensitivity and specificity or are elevated for a short time. In this systematic review, we evaluate postoperative troponin I as a predictor of postoperative myocardial infarction, mortality, and hospital and Intensive Care Unit stay. Methods This systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Review and Meta‐Analysis guidelines. A thorough literature search was conducted over PubMed, clinicaltrials. gov, and the Cochrane library from inception till?May 24, 2022 using relevant keywords, and only articles that met the pre‐defined criteria were recruited. Results Following a comprehensive literature search, a total of 359 articles were obtained. Following a rigid screening and full‐length review, only 13 studies met our inclusion criteria and were included. The recruited studies evaluated data from a total of 12,483 individuals and assessed troponin I as a predictor of at least one outcome. Conclusion Troponin I has the potential to be used as a stand‐alone predictor of surgical outcomes following coronary artery bypass grafting and valvular surgeries. However, supplementing it with other markers and scores offers the best chance at timely diagnosing any complications.
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The novel coronavirus pandemic has taken a toll on the global healthcare systems and economy. Safety precautions, along with vaccination, are the most effective preventive measures. The global vaccination program against COVID-19 ...
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The novel coronavirus pandemic has taken a toll on the global healthcare systems and economy. Safety precautions, along with vaccination, are the most effective preventive measures. The global vaccination program against COVID-19 has dramatically reduced the number of deaths and cases. However, the incidence of thrombotic events and thrombocytopenia post-COVID-19 vaccination known as vaccine-induced thrombotic thrombocytopenia has raised safety concerns. This has led to an element of vaccine hesitancy. The exact mechanism for vaccine-induced thrombotic thrombocytopenia is unknown. Although the incidence of thrombosis associated with COVID-19 vaccination is low, it still requires attention, especially in older people, smokers, and people with preexisting comorbidities. This study aims to review the pathophysiology, diagnosis, and management of vaccine-induced thrombotic thrombocytopenia, to provide a concise and comprehensive update.
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The global vaccination drive against severe acute respiratory syndrome coronavirus-2 is being pursued at a historic pace. Unexpected adverse effects have been reported following vaccination, including thrombotic thrombocytopenia, ...
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The global vaccination drive against severe acute respiratory syndrome coronavirus-2 is being pursued at a historic pace. Unexpected adverse effects have been reported following vaccination, including thrombotic thrombocytopenia, myocarditis, amongst others. More recently, some cases of tinnitus are reported post-vaccination. According to the Vaccine Adverse Events Reporting System (VAERS), 12,247 cases of coronavirus post-vaccination tinnitus have been reported till September 14, 2021. To the best of our knowledge, this is the first review evaluating any otologic manifestation following vaccine administration and aims to evaluate the potential pathophysiology, clinical approach, and treatment. Although the incidence is infrequent, there is a need to understand the precise mechanisms and treatment for vaccine-associated-tinnitus.
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Workplace violence can be considered a global challenge and a major occupational issue, especially in developing countries where healthcare services and facilities can be stretched and under-resourced. It significantly affects the...
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Workplace violence can be considered a global challenge and a major occupational issue, especially in developing countries where healthcare services and facilities can be stretched and under-resourced. It significantly affects the mental and physical health of the doctors and other staff. The estimated prevalence of work-related violence is two-thirds globally. Junior doctors and residents along with health staff serving in emergency units and psychiatry wards are at more risk. The extent of this issue is still unknown as most of the cases go unreported. Some common factors are patient and visitor dissatisfaction, low impulse control, and poor communication. Effective policies at the grass-root level and strict laws against violators is the only way to decrease ever-growing workplace violence.
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Recently, in Pakistan, several cases of mysterious dengue‐like illness are being reported, which has concerned the authorities and requires prompt action. We present a case of a 52‐year‐old female patient presenting with a hist...
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Recently, in Pakistan, several cases of mysterious dengue‐like illness are being reported, which has concerned the authorities and requires prompt action. We present a case of a 52‐year‐old female patient presenting with a history of continuous fever, documented up to 104?F, for 5?days. The symptoms were associated with headache, nausea, retro‐orbital headache, arthralgia, and myalgia. Currently, to the best of our knowledge, this is the first reported case in the literature for the endemic mysterious virus and may serve as the groundwork for future studies.
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Autoimmune encephalitis (AIE) can be caused by various neuronal surface and intracellular antibodies. The prevalence and gender predisposition vary according to the subtype involved. It can produce a wide range of neurologic or ps...
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Autoimmune encephalitis (AIE) can be caused by various neuronal surface and intracellular antibodies. The prevalence and gender predisposition vary according to the subtype involved. It can produce a wide range of neurologic or psychiatric symptoms. We present a case of a young female patient who presented to a psychiatric facility with behavioral and perceptual disturbances and was later referred to a medical department, where, through a series of investigations, she was diagnosed as a case of AIE. Unfortunately, the ultimate outcome was death due to a delay in reaching toward?accurate diagnosis. This case report highlights the lapse of the healthcare system, particularly in low- and middle-income countries at multiple levels in providing adequate health care.
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West Nile virus (WNV), a single-stranded RNA virus belonging to the family of Flaviviridae, is an arbovirus transmitted to humans predominantly by mosquito bites. It exhibits a wide range of clinical findings ranging from asymptom...
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West Nile virus (WNV), a single-stranded RNA virus belonging to the family of Flaviviridae, is an arbovirus transmitted to humans predominantly by mosquito bites. It exhibits a wide range of clinical findings ranging from asymptomatic presentation to severe several neurological disorders. WNV has afflicted several countries around the globe including Pakistan. News of yet another outbreak in the country by WNV is circulating again. Concerned authorities should act vigilantly before the endemic takes over completely and bring down the already bereaving healthcare of Pakistan.
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